Crown Bioscience Reinforces Global Immuno-Oncology Platform

Crown Bioscience Reinforces Global Immuno-Oncology Platform
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Crown Bioscience is strengthening its global immuno-oncology platform at its facilities in Europe, U.S. and Asia to support immuno-oncology client needs with a broad assortment of validated models and services for pharmacodynamics and efficacy studies in animals.

“In response to the growing demand for Immuno-Oncology translational services, CrownBio is now able to offer at its local facilities immunophenotyping analysis, including multi-color flow cytometry, immunohistochemistry and multiplex ELISA on our world-leading collection of Immuno-Oncology models, to rapidly profile and investigate the impact of experimental therapies on both murine and human immune systems,” said Jean Pierre Wery, President of Crown Bioscience, in a press release.

The announcement comes on the heals of the company’s recent launch of the new immuno-oncology model, HuGEMM.

“Up until now, the lack of models available to test the in vivo efficacy of new antibody-based immunotherapies and combination therapies has hindered the research process,” said Wery. “With HuGEMM, there is now a robust model system in place to enable scientists to assess the efficacy of human biologic therapeutics directly without resorting to mouse surrogates.”

Crown Bioscience has a unique collection of certified syngeneic models designed for checkpoint inhibitors besides HuGEMM –  like MiXeno, MuPrime and humanized PDX platforms. All models can be comprehensively profiled using immunophenotyping tools for pharmacodynamic readouts of before-treatment baseline and after-treatment outcomes in order to better understand the effect on the immune system.

“In particular, single cell-based FACS analysis has become a standard and essential tool to investigate the impact of immuno-oncology therapy in both murine and humanized systems in the preclinical setting. Our ability to perform FACS analysis locally as part of our in vivo services offering will undoubtedly represent a key add-on technology for our clients,” added Henry Li, the company’svice president of Translational Oncology. “The ability to gate different sub-populations of T lymphocytes and myeloid compartment provides a rapid way for our clients to understand the impact of both single and combination therapies to significantly extend the reach of potential therapeutic effect across a larger population of patients.”

Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
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Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.
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