Melanoma is the most serious type of skin cancer. It is usually a result of extensive exposure to ultra-violet radiation from the sun or artificial light sources such as tanning beds.
How HF10 works
HF10 is an oncolytic immunotherapy. This new approach to fighting cancer involves using oncolytic viruses to go after malignancies.
An oncolytic virus is one whose preferred target is cancer. A key advantage of using HF10 to fight cancer is that it multiplies only in tumor cells, and does not affect healthy tissue.
Another advantage is that the strong response that HF10 generates against cancer enhances the body’s natural anti-tumor activity.
HF10 in clinical trial
Participants have either stage 3B, 3C or 4 metastatic malignant melanoma that surgery has failed to remove completely.
Researchers are injecting HF10 directly into patients’ tumors and administering Yervoy by IV infusion. Yerboy is an immune checkpoint inhibitor that enhances antitumor immunity.
Preliminary results indicate that HF10 substantially improves Yervoy’s effectiveness without increasing its toxicity. In addition, patients have tolerated the combination well, researchers said. The findings so far suggest that the combo could be an effective way to treat metastatic melanoma, the team said.
The trial is ongoing at several U.S. locations. It is not recruiting more participants.
A similar Phase 2 study (NCT03153085) is evaluating the combo’s ability to treat metastatic malignant melanoma patients in Japan.
Takara is also assessing a combination of HF10 and chemotherapy as a treatment for pancreatic cancer. A Phase 1 clinical trial (NCT03252808) that it is conducting in Japan involves patients with stage 3 or 4 pancreatic cancer that surgery has failed to remove completely. Results are expected in early 2019.
Immuno-Oncology News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Immuno-oncology News, or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to Immuno-oncology.