Posts by: Ana Pamplona, PhD

Ana Pamplona, PhD

I have a PhD in Biochemistry from the Faculty of Science and Technology from Lisbon (UNL), Portugal. I did my post-doctoral research in Malaria with Prof. Maria Mota at Instituto de Medicina Molecular and Instituto Gulbenkian de Ciência for 6 years. Between 2009 and 2014, I have been a Staff Scientist (Programa Ciência 2008) in the T cell differentiation and Tumor targeting Lab at Instituto de Medicina Molecular, headed by Prof. Bruno Silva-Santos, where I continued studying malaria pathogenesis.

April 16, 2015April 16, 2015

Memorial Sloan Kettering To Initiate First Pediatric CAR T Cell Clinical Study

News

A new cutting-edge clinical trial is being developed specifically for children and young adults with relapsed or treatment-resistant acute lymphocytic leukemia (ALL) using cutting-edge chimeric antigen receptor (CAR) T cell immunotherapy. The ... Read more

April 14, 2015April 14, 2015

Development and Commercialization Agreement for CAR-T Therapy Established by Intrexon and Merck Serono

News

Intrexon Corporation , a pioneer in synthetic biology, and Merck Serono, the biotechnology and pharmaceutical company of Merck KGaA, Germany, established a collaborative licensing agreement for the development and commercialization ... Read more

March 31, 2015March 31, 2015

HER2-specific T cells As An Immunotherapy In HER2-Positive Sarcoma

News

A clinical trial recently showed promising results for a new type of immunotherapy for HER2-positive sarcoma. The study entitled ”Human Epidermal Growth Factor Receptor 2 (HER2) – Specific Chimeric Antigen ... Read more

March 20, 2015March 20, 2015

Identification of Metabolic Pathways Involved in Macrophage Polarization Regulation

News

A recent study revealed new metabolic mechanisms that regulate macrophage polarization, a property of macrophages in changing their functional activity depending on the local microenvironment. A new study entitled “Network Integration ... Read more

March 19, 2015March 19, 2015

Melanoma-associated Macrophages Appear to be Crucial for Resistance to BRAF Inhibitors

News

Researchers from The Wistar Institute discovered that macrophages have a crucial role in melanoma resistance to targeted therapies. The study entitled “BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth” ... Read more

March 17, 2015March 17, 2015

Modified Immunotoxin as Potential Therapy for Patients With B-cell Malignancies

News

Researchers from the University of Minnesota developed an immunotoxin to target B-cell tumors. The study entitled “Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for ... Read more

March 11, 2015March 11, 2015

Study Finds Novel Method To Improve Cancer Immunotherapy

News

A breakthrough finding in cancer therapy was discovered by researchers from Northeastern University who found increased oxygenation could decrease tumors and improve cancer immunotherapy. The study, entitled “Immunological mechanisms of the anti tumor ... Read more

March 10, 2015March 10, 2015

Immune Cell’s Metabolism Essential For Adequate Immune-Mediated Tumor Response

News

A new study identified the human antigen R (HuR) as a critical protein for controlling the balance of energy metabolism required for an adequate function of immune cells to develop immunity ... Read more

March 6, 2015March 6, 2015

Vectibix Combined with FOLFIRI Chemotherapy as First-Line Therapy For Metastatic Colorectal Cancer

News

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) gave a positive opinion to extend the marketing authorization for Vectibix (panitumumab) (Amgen) to be included ... Read more

March 3, 2015March 3, 2015

Novel Test Links Immune Hotspots to Improved Breast Cancer Prognosis

News

A recent study established an automated histological image processing technique to quantify spatial heterogeneity in the distribution patterns of tumor-infiltrating lymphocytes (TILs) in breast cancer. The study entitled “Beyond immune density: ... Read more