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September 18, 2018September 18, 2018

Targeting Tumor Microenvironment Could Improve Response to Immunotherapies in Urothelial Cancer, Study Finds

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The cells that support tumors — generally called stromal cells — play a significant part in the resistance to immune checkpoint inhibitor therapies seen in some urothelial cancers, according to a ... Read more

September 14, 2018September 14, 2018

Keytruda and Chemotherapy Combo Now 1st-Line Treatment for Advanced NSCLC in EU

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The European Commission approved the use of Keytruda (pembrolizumab), in combination with Alimta (pemetrexed) and platinum-based chemotherapy, as a first-line treatment for metastatic nonsquamous non-small cell lung cancer (NSCLC). The approval is ... Read more

September 12, 2018September 12, 2018

‘Switchable’ CAR T-cell Therapy Kills Advanced Pancreatic Cancer Cells in Mice, Study Reports

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A “switchable” CAR T-cell immunotherapy was able to completely eliminate cancer in mice whose tumors came from cells of people with advanced pancreatic cancer, including cancer cells that had moved ... Read more

September 11, 2018September 11, 2018

StemVacs Cancer Vaccine Shows Safety in Phase 1 Study and May Be Eligible for Right to Try, Therapeutic Solutions Says

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StemVacs, a cell-based immunotherapy vaccine platform that targets cancer stem cells, was well-tolerated by 10 patients with multiple advanced cancers who took part in a Phase 1 safety trial, ... Read more

September 7, 2018September 7, 2018

Affimed and Genentech Partner to Develop Immunotherapies Against Cancer Based on Natural Killer Cells

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A recent collaboration between Affimed and Genentech, a member of the Roche group, aims to develop immunotherapies — called engager-based immunotherapies — that aim to establish a bridge between a patient’s own immune cells and ... Read more

September 5, 2018

New UNC Software Aims to Make Stem Cell Transplants Safer for Leukemia Patients

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New computer software is able to identify targets for potential immunotherapies in individual leukemia patients undergoing stem cell transplants, a new study shows. These results open the door for tailored ... Read more

September 4, 2018

Adlai Nortye Opens Boston Site to Advance Cancer Treatments

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Adlai Nortye has opened its first U.S. innovation center, in Boston, Massachusetts. The China-based company is dedicated to the development of treatments for metabolic diseases and cancer. The Boston ... Read more

August 30, 2018August 31, 2018

Blocking Cellular Pathway May Make Radiotherapy More Effective by Activating Immune System, Early Study Reports

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Targeting a specific cellular pathway may improve the effectiveness of radiotherapy given to cancer patients by activating the immune system, according to a study in mice. The research, “Non-canonical NF-κB ... Read more

August 30, 2018August 30, 2018

Mutations in MUC16 Gene May Help Define Immunotherapy Strategies for Gastric Cancer, Study Suggests

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Mutations in the MUC16 gene may help predict disease outcome and provide treatment guidance for gastric cancer patients, researchers suggest. These mutations are also linked to a higher mutational burden, ... Read more

August 28, 2018August 28, 2018

New Scoring System May Help Predict Patient Response to Checkpoint Inhibitors, Study Reports

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A newly developed scoring system could help identify melanoma patients who may benefit the most from treatment with a type of immunotherapy known as a checkpoint inhibitor, a study finds. ... Read more

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