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January 23, 2020January 29, 2020

FDA to Review Tecentriq-Avastin Combo for Newly Diagnosed Advanced Liver Cancers

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Genentech has submitted an application to the U.S. Food and Drug Administration to extend the use of Tecentriq (atezolizumab), in combination with Avastin (bevacizumab), for the treatment of people with ... Read more

January 22, 2020

First Patient Dosed in Phase 1/2 Trial Testing HB-201 Vaccine for HPV16+ Cancers, Hookipa Pharma Announces

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The first patient has been dosed in a Phase 1/2 trial testing Hookipa Pharma‘s experimental cancer vaccine HB-201, alone or in combination with an immune checkpoint inhibitor, in people with ... Read more

January 20, 2020May 19, 2020

FDA Grants Priority Review to Opdivo-Yervoy Combo as First-Line Treatment for Advanced NSCLC

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Note: This story was updated May 19, 2020, to note that Opdivo binds to PD-1 on immune T-cells, not to PD-L1 on tumor cells. The U.S. Food and Drug Administration ... Read more

January 17, 2020January 17, 2020

Phase 2 Trial in Belarus Examines DNA Vaccine, Elenagen, for Advanced Solid Cancers

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The Alexandrov National Cancer Centre in Belarus has initiated a Phase 2 clinical trial to test a new DNA vaccine, Elenagen, in patients with inoperable, late-stage cancers affecting the breast, ... Read more

January 15, 2020

Dosing Begins in Study of Immune Checkpoint Inhibitor, Alone or in Combo, for Solid Tumors

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A Phase 1 trial to treat advanced solid tumors has dosed its first patient with a combination of AGEN1181, a next generation CTLA-4 inhibitor, and the PD-1 inhibitor balstilimab — two ... Read more

January 13, 2020January 13, 2020

University of Chicago Researcher Wins Immuno-oncology Award from European Society

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Thomas Gajewski, professor of cancer immunotherapy and pathology and medicine at University of Chicago Medicine, won the 2019 European Society for Medical Oncology (ESMO) Award for Immuno-Oncology in recognition of ... Read more

January 9, 2020February 6, 2020

Dosing Begins in Phase 1 Trial of AGEN1223 Antibody for Advanced Solid Tumors

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A Phase 1 clinical trial for people with advanced solid cancers has dosed its first participant with Agenus‘ investigational antibody, AGEN1223, a therapy designed to improve immune system efficiency in ... Read more

January 8, 2020

BioNTech’s CAR T-cell Therapy, Accompanying Vaccine Demonstrate High Anti-tumor Activity in Solid Tumors, Mouse Study Shows

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Claudin 6, a cell surface protein involved in cell junction formation, may be a promising target for CAR T-cell therapies against solid tumors, according to a proof-of-concept study in mice. ... Read more

January 3, 2020January 3, 2020

Tislelizumab-Chemo Combo Induces Durable Responses in Patients with Stomach, Esophagus Cancers, Trial Data Show

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Treatment with Beigene‘s experimental therapy tislelizumab and chemotherapy resulted in durable responses and was overall well-tolerated in Chinese people with gastric/gastroesophageal junction (G/GEJ) adenocarcinoma or esophageal squamous cell carcinoma (ESCC), preliminary ... Read more

December 18, 2019December 18, 2019

Adding BL-8040 to Keytruda and Chemo Shows Good Disease Control in Pancreatic Cancer, Phase 2 Trial Shows

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Treatment with investigational BL-8040, in combination with Keytruda (pembrolizumab) and chemotherapy, leads to promising response and disease control rates in people with metastatic pancreatic cancer who progressed after first-line therapy, ... Read more