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June 29, 2018June 29, 2018

Combination of Immune Cells Improves Chances of Successful Immunotherapy

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Immunotherapy with checkpoint inhibitors is more effective in cancer patients who have elevated numbers of specific types of immune cells inside their tumors, a study suggests. Patients with a favorable combination ... Read more

June 27, 2018June 27, 2018

DNA Vaccine To Be Tested in Advanced Colorectal Cancer Patients for 1st Time in Phase 1/2 Trial

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Researchers in Australia are testing for a first time the safety and efficacy of a DNA-based vaccine to treat advanced colorectal cancer in people with this disease, after promising results in ... Read more

June 26, 2018June 26, 2018

Gene Editing of Healthy Cells Improves CAR T-cell Therapy for AML, Preclinical Study Shows

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Genetic modification of healthy blood stem cells prevents off-target effects of chimeric antigen receptor (CAR) T-cell therapy for treating acute myeloid leukemia (AML), a recent preclinical study shows. The study, “Genetic ... Read more

June 22, 2018

First Cancer Patient Dosed in Trial Investigating Immunotherapy ADXS-NEO

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The first patient has been dosed in a Phase 1 clinical trial testing ADXS-NEO, a potential cancer immunotherapy designed to activate immune system responses against the unique mutations in each ... Read more

June 20, 2018

Older Melanoma Patients Respond Better to Anti-PD-1 Immunotherapies, Study Shows

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Older melanoma patients respond better to the anti-PD-1 immunotherapy Keytruda (pembrolizumab), according to new data from a multinational study. Researchers are attributing these differences to a reduced immunosuppressive tumor environment in ... Read more

June 19, 2018

Immunotherapy Candidate M7824 Effective in Advanced Lung Cancer Patients, Phase 1 Trial Shows

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M7824, an immunotherapy candidate being developed by EMD Serono, reduced tumor size in a significant number of patients with advanced non-small cell lung cancer (NSCLC), Phase 1 data shows. Updated trial results were ... Read more

June 15, 2018June 15, 2018

Keytruda-Chemo Combo Shows Superior Anti-cancer Response in Metastatic NSCLC Phase 3 Trial

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Adding Keytruda (pembrolizumab) to chemotherapy provides superior and more sustained tumor size reduction in patients with a type of metastatic non-small cell lung cancer (NSCLC), Merck’s Phase 3 trial shows. ... Read more

June 13, 2018June 13, 2018

Men, Women Respond Differently to Immunotherapies Used in Advanced Cancer Treatment, Study Shows

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Men and women may benefit differently from immunotherapy medications used to treat several types of advanced cancers, according to a review study. The study, “Cancer immunotherapy efficacy and patients’ sex: a ... Read more

June 12, 2018June 12, 2018

Apogenix Updates Data on Asunercept, Prepares Submission for Conditional Marketing Authorization in Europe

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Asunercept (APG101), an inhibitor of the CD95 ligand, significantly extended the survival of recurrent glioblastoma patients included in a Phase 2 trial, according to Apogenix, the investigational therapy’s maker. Five years ... Read more

June 8, 2018

Immunotherapy Targeting Tumor Mutations Leads to Complete Response in Advanced Breast Cancer Patient, NIH Reports

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A tweaked version of a cellular immunotherapy that recognizes mutations in a patient’s tumor has led to the complete regression of metastatic breast cancer in a woman whose disease had ... Read more