Opdivo Improves Long-Term Survival in Advanced Lung Cancer, Data Show

Opdivo Improves Long-Term Survival in Advanced Lung Cancer, Data Show

Opdivo (nivolumab) outperformed the cancer drug Taxotere (docetaxel) in clinical trials of advanced and earlier treated lung cancer, with survival rates about double those seen with the older treatment after three years.

Researchers from the Vall d’Hebron University Hospital in Spain, who led the study, presented the data at the European Society for Medical Oncology (ESMO) 2017 Congress in Madrid, Spain.

The presentation, “Three-year follow-up from CheckMate 017/057: Nivolumab versus docetaxel in patients with previously treated advanced non-small cell lung cancer (NSCLC),” was given on Sept. 10.

The two treatment approaches were compared in two Phase 3 clinical trials. One, called CheckMate -017 (NCT01642004), included 272 patients with squamous non-small cell lung cancer (NSCLC). The other, CheckMate -057 (NCT01673867) focused on non-squamous NSCLC and included 582 patients. All patients received the treatment as a second line, following one failed platinum-based chemotherapy regimen.

The study looked at the outcomes after a minimum of 36.6 months and noted that overall survival was clearly improved with Opdivo treatment. At three years, 16% of squamous NSCLC patients treated with Opdivo were still alive. Among those who had been treated with Taxotere, that number was 6%.

Similar rates were achieved in patients with non-squamous disease, in which 18% of Opdivo-treated and 9% of Taxotere-treated patients were still alive at three years.

“Opdivo is already a standard of care in previously treated non-small cell lung cancer across histologies, demonstrating durable, long-term survival in two pivotal Phase 3 studies. Data from CheckMate -017 and CheckMate -057 continue to reinforce the compelling and sustained survival benefit demonstrated with Opdivo for these patients even after three years,” Enriqueta Felip, MD, head of the Thoracic Tumors Group at Vall d’Hebron Institute of Oncology, said in a press release.

“These results are important for the clinical community and represent the longest follow-up data reported for a PD-1 inhibitor versus chemotherapy in second-line NSCLC,” she added.

Opdivo is a checkpoint inhibitor targeting the PD-1 molecule. The trials had recruited patients irrespective of their levels of the PD-L1 molecule, which earlier studies argued would be predicting of response to PD-1 blockers.

The studies showed that patients who had PD-L1 levels of less than 1% also benefitted from the treatment. Among patients with squamous cancer, survival rates were nearly identical in patients with higher and lower levels of the factor — 13% and 14%, respectively.

Non-squamous lung cancer patients with high levels of PD-L1 had a somewhat better survival rate than those with low levels —  26% compared with 11%.

Of the 427 patients who received Opdivo in the two studies, 17% survived for three years or longer.

Researchers also reported that the safety and side effects profile of Opdivo was similar to that observed in earlier studies.

“Our utmost priority at BMS [Bristol-Myers Squibb] is to bring forth transformational medicines to deliver what matters most to patients fighting cancer: long-term survival,” said Nick Botwood, MD, development lead, thoracic cancers at Bristol-Myers Squibb.

“The long-term survival benefit seen with Opdivo in the pivotal CheckMate -017 and -057 studies demonstrates our commitment to this vision. These data also increase our understanding of the value Opdivo may bring to patients with previously treated metastatic NSCLC, as we continue to explore Opdivo alone and in combination with other agents across a range of thoracic cancers.”


  1. Zina Skowronek says:

    My husband ( if insurance pays for it) is going to go on Opdivo. I’m really concerned about the side effects and what I should expect.

  2. Ron Sargent says:

    I have been on Opdivo since Feb, 2018. Prior to that I was on Alimta/Avastin after a 4 cycle treatment of Carboplatin/Alimta/Avastain. I was started on Opdivo because progression had occurred and my tumors were growing. After four months and 8 treatments with Opdivo my main tumor had shrank by 20% and the additional mets in my chest lymph nodes and chest area had been reduced in sized significantly with two almost resolved. I have an additional met in my left rib that was stabilized by radiation and is still stable. The MRI and CT scan did not reveal any additional spread. The only side effects I suffered were shaking with the first two. The doctors began introducing a corticosteroid during the IV process prior to delivering the Opdivo. That solved that issue and only other noticeable effect has been some mild soreness in the joints. (shoudler and hips). I am very excited about the possible long term benefits of this drug.

  3. ken koch says:

    I received opdivo in 2010 to 2012 now I receive two checkup a year and live a normal life in 2018. It was a life saver for me .

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